Head to head

CO2RE vs UltraPulse Alpha (2026)

Compare purchase costs, running costs and the evidence behind each device.

Read the comparison overview

Purchase cost: No new-price range is on file for either CO2RE or UltraPulse Alpha. Request current quotes to compare purchase costs.
Practice fit: Both are listed under CO2 fractional/ablative. Check each model’s US regulatory status and labeled indications for your intended use.

Device A

CO2 Fractional/Ablative

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Device B

CO2 Fractional/Ablative

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Price comparison

Price comparison: Candela CO2RE vs Lumenis UltraPulse Alpha
Attribute	Candela CO2RE	Lumenis UltraPulse Alpha
New price range	Not published	Not published
Used price reference	$25k–$45kSource not documented	$70k–$110kSource not documented
Payback calculator	View ROI calculator	View ROI calculator
Next step

New price range

Candela CO2RE: Not published
Lumenis UltraPulse Alpha: Not published

Used price reference

Candela CO2RE: $25k–$45kSource not documented
Lumenis UltraPulse Alpha: $70k–$110kSource not documented

Payback calculator

Candela CO2RE: View ROI calculator
Lumenis UltraPulse Alpha: View ROI calculator

Next step

Candela CO2RE

Lumenis UltraPulse Alpha

Supplies & running costs

Supplies & running costs: Candela CO2RE vs Lumenis UltraPulse Alpha
Attribute	Candela CO2RE	Lumenis UltraPulse Alpha
Supplies & restrictions	Supply pricing is not documented with a dated source yet. Request an itemized supply quote. View running-cost details	Supply pricing is not documented with a dated source yet. Request an itemized supply quote. View running-cost details

Supplies & restrictions

Candela CO2RE: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
View running-cost details
Lumenis UltraPulse Alpha: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
View running-cost details

FDA status & indications

FDA status & indications: Candela CO2RE vs Lumenis UltraPulse Alpha
Attribute	Candela CO2RE	Lumenis UltraPulse Alpha
FDA status & indication	FDA record cited — see scopeK151655, K181523 Record scope: K181523 names the CO2RE Laser System and includes separate standard, fractional and surgical handpiece indications. K151655 is the earlier cited platform record. Included handpieces and applicable labeling determine scope; a platform clearance is not a statement that every accessory is supplied. Read FDA indication wording “The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”	FDA ClearedK233301 Read FDA indication wording “The Modified ULTRApulse Alpha CO2 Laser System, Delivery Devices and Accessories (members of the UltraPulse CO2 Laser Systems Family) is indicated for use in surgical or aesthetic applications requiring: ablation, vaporization, excision, incision, or coagulation of soft tissue in medical specialties including: dermatology and plastic surgery (aesthetic), podiatry, gynecology, general and thoracic surgery, dental and oral surgery and genitourinary surgery as follows: Dermatology & Plastic Surgery — The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: • Laser skin resurfacing • Laser derm-abrasion • Laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for treatment of: • Wrinkles, rhytids, and furrows (including fine lines and texture irregularities). Laser skin resurfacing (ablation and/or vaporization) of soft tissue for the reduction, removal, and/or treatment of: • Keratoses, including actinic and seborrheic keratosis, seborrhoecae vulgares, seborrheic wart and verruca seborrheica • Vermillionectomy of the lip • Cutaneous horns • Solar/actinic elastosis • Cheilitis, including actinic cheilitis • Lentigines, including lentigo maligna or Hutchinson's malignant freckle • Uneven pigmentation/dyschromia • Acne scars • Surgical scars • Keloids including acne keloidalis nuchae • Hemangiomas (including Buccal, port wine and pyogenic granulomas/granuloma pyogenicum/granuloma telangiectaticum) • Tattoos • Telangiectasia • Removal of small skin tumors, including periungual (Koenen) and subungual fibromas • Superficial pigmented lesions • Adenosebaceous hypertrophy or sebaceous hyperplasia • Rhinophyma reduction • Cutaneous papilloma (skin tags) • Milia • Debridement of eczematous or infected skin • Basal and squamous cell carcinoma, including keratoacanthomas, Bowen's disease (Erythroplasia of Queyrat), and Bowenoid Papulosis (BP) lesions • Nevi, including spider, epidermal and protruding • Neurofibromas • Laser de-epithelialization • Tricoepitheliomas • Xanthelasma palpebrarum […]”

FDA status & indication

Candela CO2RE: FDA record cited — see scopeK151655, K181523
Record scope: K181523 names the CO2RE Laser System and includes separate standard, fractional and surgical handpiece indications. K151655 is the earlier cited platform record. Included handpieces and applicable labeling determine scope; a platform clearance is not a statement that every accessory is supplied.
Read FDA indication wording
“The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”
Lumenis UltraPulse Alpha: FDA ClearedK233301
Read FDA indication wording
“The Modified ULTRApulse Alpha CO2 Laser System, Delivery Devices and Accessories (members of the UltraPulse CO2 Laser Systems Family) is indicated for use in surgical or aesthetic applications requiring: ablation, vaporization, excision, incision, or coagulation of soft tissue in medical specialties including: dermatology and plastic surgery (aesthetic), podiatry, gynecology, general and thoracic surgery, dental and oral surgery and genitourinary surgery as follows: Dermatology & Plastic Surgery — The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: • Laser skin resurfacing • Laser derm-abrasion • Laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for treatment of: • Wrinkles, rhytids, and furrows (including fine lines and texture irregularities). Laser skin resurfacing (ablation and/or vaporization) of soft tissue for the reduction, removal, and/or treatment of: • Keratoses, including actinic and seborrheic keratosis, seborrhoecae vulgares, seborrheic wart and verruca seborrheica • Vermillionectomy of the lip • Cutaneous horns • Solar/actinic elastosis • Cheilitis, including actinic cheilitis • Lentigines, including lentigo maligna or Hutchinson's malignant freckle • Uneven pigmentation/dyschromia • Acne scars • Surgical scars • Keloids including acne keloidalis nuchae • Hemangiomas (including Buccal, port wine and pyogenic granulomas/granuloma pyogenicum/granuloma telangiectaticum) • Tattoos • Telangiectasia • Removal of small skin tumors, including periungual (Koenen) and subungual fibromas • Superficial pigmented lesions • Adenosebaceous hypertrophy or sebaceous hyperplasia • Rhinophyma reduction • Cutaneous papilloma (skin tags) • Milia • Debridement of eczematous or infected skin • Basal and squamous cell carcinoma, including keratoacanthomas, Bowen's disease (Erythroplasia of Queyrat), and Bowenoid Papulosis (BP) lesions • Nevi, including spider, epidermal and protruding • Neurofibromas • Laser de-epithelialization • Tricoepitheliomas • Xanthelasma palpebrarum […]”

Which chains run each

Which chains run each: Candela CO2RE vs Lumenis UltraPulse Alpha
Attribute	Candela CO2RE	Lumenis UltraPulse Alpha
Chain adoption	0 recorded pairings	0 recorded pairings
Chains using it	—	—
Approved reviews	0	0

Chain adoption

Candela CO2RE: 0 recorded pairings
Lumenis UltraPulse Alpha: 0 recorded pairings

Chains using it

Candela CO2RE: —
Lumenis UltraPulse Alpha: —

Approved reviews

Candela CO2RE: 0
Lumenis UltraPulse Alpha: 0

Specs and platform

Specs and platform: Candela CO2RE vs Lumenis UltraPulse Alpha
Attribute	Candela CO2RE	Lumenis UltraPulse Alpha
Manufacturer	Candela	Lumenis
Built by (OEM)	Syneron Medical Ltd.	Lumenis Be Ltd.
Category	CO2 Fractional/Ablative	CO2 Fractional/Ablative
Technology	Fractional CO2 10600nm dual-ring scanning (CO2 fractional)	CO2 10600nm high-energy fractional (CO2 fractional)
Launch year	2011	2019
Status	Current	Current
Manufacturing relationship evidence	No separate manufacturing-relationship record linked.	No separate manufacturing-relationship record linked.

Manufacturer

Candela CO2RE: Candela
Lumenis UltraPulse Alpha: Lumenis

Built by (OEM)

Candela CO2RE: Syneron Medical Ltd.
Lumenis UltraPulse Alpha: Lumenis Be Ltd.

Current alternatives

Current catalog models in related categories. Confirm availability and configuration with the supplier.

Alma Hybrid

CO2 Fractional/Ablative

New-equipment price not yet documented.

Cynosure Lutronic eCO2 3D

CO2 Fractional/Ablative

New-equipment price not yet documented.

DEKA HELIX

CO2 Fractional/Ablative

New-equipment price not yet documented.

DEKA SmartXide Punto

CO2 Fractional/Ablative

New-equipment price reference

$60k–$90k

Source not documented

Check the profile for configuration and price details.

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