Head to head

CO2RE vs MonaLisa Touch (2026)

Compare purchase costs, running costs and the evidence behind each device.

Read the comparison overview

Purchase cost: Catalog new-price ranges: CO2RE, $90k–$120k; MonaLisa Touch, $100k–$140k. Check the source notes and request current quotes.
Practice fit: CO2RE: CO2 fractional/ablative. MonaLisa Touch: fractional CO2 (gynecologic). Check each model’s US regulatory status and labeled indications for your intended use.

Device A

CO2 Fractional/Ablative

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Device B

Fractional CO2 (gynecologic)

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Price comparison

Price comparison: Candela CO2RE vs Cynosure MonaLisa Touch
Attribute	Candela CO2RE	Cynosure MonaLisa Touch
New price range	$90k–$120kSource not documented	$100k–$140kSource not documented
Used asking range	$25k–$45kSource not documented	$20k–$50kSource not documented
Payback calculator	View ROI calculator	View ROI calculator
Next step

New price range

Candela CO2RE: $90k–$120kSource not documented
Cynosure MonaLisa Touch: $100k–$140kSource not documented

Used asking range

Candela CO2RE: $25k–$45kSource not documented
Cynosure MonaLisa Touch: $20k–$50kSource not documented

Payback calculator

Candela CO2RE: View ROI calculator
Cynosure MonaLisa Touch: View ROI calculator

Next step

Candela CO2RE

Cynosure MonaLisa Touch

Consumable economics

Consumable economics: Candela CO2RE vs Cynosure MonaLisa Touch
Attribute	Candela CO2RE	Cynosure MonaLisa Touch
Consumable cost / lock-in	Supply pricing is not documented with a dated source yet. Request an itemized supply quote.	Low per-case — single-use probe covers/hygiene barriers and smoke-evac supplies (tens of dollars); the meaningful lifecycle cost is eventual CO2 tube/optics service.
Service cost	Not published	Not published

Consumable cost / lock-in

Candela CO2RE: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
Cynosure MonaLisa Touch: Low per-case — single-use probe covers/hygiene barriers and smoke-evac supplies (tens of dollars); the meaningful lifecycle cost is eventual CO2 tube/optics service.

Service cost

Candela CO2RE: Not published
Cynosure MonaLisa Touch: Not published

FDA clearance

FDA clearance: Candela CO2RE vs Cynosure MonaLisa Touch
Attribute	Candela CO2RE	Cynosure MonaLisa Touch
FDA status & indication	FDA ClearedK151655, K181523 Read FDA indication wording “The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”	FDA ClearedK133895 Read FDA indication wording “It is indicated for incision, excision, ablation, vaporization and coagulation of body soft tissues in medical specialties including aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynaecology, neurosurgery, orthopaedics, general and thorasic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery. The use with the scanning unit is indicated for ablative skin resurfacing.”

FDA status & indication

Candela CO2RE: FDA ClearedK151655, K181523
Read FDA indication wording
“The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”
Cynosure MonaLisa Touch: FDA ClearedK133895
Read FDA indication wording
“It is indicated for incision, excision, ablation, vaporization and coagulation of body soft tissues in medical specialties including aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynaecology, neurosurgery, orthopaedics, general and thorasic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery. The use with the scanning unit is indicated for ablative skin resurfacing.”

Which chains run each

Which chains run each: Candela CO2RE vs Cynosure MonaLisa Touch
Attribute	Candela CO2RE	Cynosure MonaLisa Touch
Chain adoption	0 recorded pairings	0 recorded pairings
Chains using it	—	—
Approved reviews	0	0

Chain adoption

Candela CO2RE: 0 recorded pairings
Cynosure MonaLisa Touch: 0 recorded pairings

Chains using it

Candela CO2RE: —
Cynosure MonaLisa Touch: —

Approved reviews

Candela CO2RE: 0
Cynosure MonaLisa Touch: 0

Specs and platform

Specs and platform: Candela CO2RE vs Cynosure MonaLisa Touch
Attribute	Candela CO2RE	Cynosure MonaLisa Touch
Manufacturer	Candela	Cynosure
Built by (OEM)	Syneron Medical Ltd.	Cynosure LLC
Category	CO2 Fractional/Ablative	Fractional CO2 (gynecologic)
Technology	Fractional CO2 10600nm dual-ring scanning (CO2 fractional)	DEKA SmartXide fractional CO2 with intravaginal probe (CO2 fractional)
Launch year	2011	2015
Status	Current	Current
Manufacturer source record	No linked source on file.	No linked source on file.

Manufacturer

Candela CO2RE: Candela
Cynosure MonaLisa Touch: Cynosure

Built by (OEM)

Candela CO2RE: Syneron Medical Ltd.
Cynosure MonaLisa Touch: Cynosure LLC

Current alternatives

Current catalog models in related categories. Confirm availability and configuration with the supplier.

Rohrer Aesthetics Phoenix CO2

CO2 Fractional/Ablative

New: $59,995 (Rohrer-advertised price)

Lumenis AcuPulse

CO2 Fractional/Ablative

New: $90k–$130k

DEKA SmartXide Punto

CO2 Fractional/Ablative

New: $60k–$90k

DEKA HELIX

CO2 Fractional/Ablative

New: —

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