Head to head

CO2RE vs UltraPulse DUO (2026)

Compare purchase costs, running costs and the evidence behind each device.

Read the comparison overview

Purchase cost: The catalog lists $90k–$120k for CO2RE. No new-price range is on file for UltraPulse DUO. Check the source notes and request current quotes.
Practice fit: Both are listed under CO2 fractional/ablative. Check each model’s US regulatory status and labeled indications for your intended use.

Device A

CO2 Fractional/Ablative

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Device B

CO2 Fractional/Ablative

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Price comparison

Price comparison: Candela CO2RE vs Lumenis UltraPulse DUO
Attribute	Candela CO2RE	Lumenis UltraPulse DUO
New price range	$90k–$120kSource not documented	Not published
Used asking range	$25k–$45kSource not documented	$35k–$65kSource not documented
Payback calculator	View ROI calculator	View ROI calculator
Next step		Explore this model’s specs and owner reviews. For new-equipment inquiries, browse current models. Browse current models

New price range

Candela CO2RE: $90k–$120kSource not documented
Lumenis UltraPulse DUO: Not published

Used asking range

Candela CO2RE: $25k–$45kSource not documented
Lumenis UltraPulse DUO: $35k–$65kSource not documented

Payback calculator

Candela CO2RE: View ROI calculator
Lumenis UltraPulse DUO: View ROI calculator

Next step

Candela CO2RE

Lumenis UltraPulse DUO

Explore this model’s specs and owner reviews. For new-equipment inquiries, browse current models.

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Consumable economics

Consumable economics: Candela CO2RE vs Lumenis UltraPulse DUO
Attribute	Candela CO2RE	Lumenis UltraPulse DUO
Consumable cost / lock-in	Supply pricing is not documented with a dated source yet. Request an itemized supply quote.	—
Service cost	Not published	Not published

Consumable cost / lock-in

Candela CO2RE: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
Lumenis UltraPulse DUO: —

Service cost

Candela CO2RE: Not published
Lumenis UltraPulse DUO: Not published

FDA clearance

FDA clearance: Candela CO2RE vs Lumenis UltraPulse DUO
Attribute	Candela CO2RE	Lumenis UltraPulse DUO
FDA status & indication	FDA ClearedK151655, K181523 Read FDA indication wording “The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”	FDA ClearedK151331, K203544, K220467 Read FDA indication wording “The UltraPulse system (UltraPulse and UltraPulse DUO models, members of the modified Lumenis Family of UltraPulse SurgiTouch CO2 Surgical Lasers) is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynecology (including laparoscopy), neurosurgery, orthopedics (soft tissue), arthroscopy (knee), general and thoracic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery. The UltraPulse system (UltraPulse and UltraPulse DUO models, members of the modified Lumenis Family of UltraPulse SurgiTouch CO2 Surgical Lasers) is indicated for use in the performance of specific surgical applications in aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynecology (including laparoscopy), neurosurgery, orthopedics (soft tissue), arthroscopy (knee), general and thoracic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery as follows: Dermatology & Plastic Surgery — The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: • Laser skin resurfacing • Laser derm-abrasion • Laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for treatment of: • Wrinkles, rhytids, and furrows (including fine lines and texture irregularities). Laser skin resurfacing (ablation and/or vaporization) of soft tissue for the reduction, removal, and/or treatment of: • Keratoses, including actinic and seborrheic keratosis, seborrhoecae vulgares, seborrheic wart and verruca seborrheica • Vermillionectomy of the lip • Cutaneous horns • Solar/actinic elastosis • Cheilitis, including actinic cheilitis • Lentigines, including lentigo maligna or Hutchinson's malignant freckle • Uneven pigmentation/dyschromia • Acne scars • Surgical scars • Keloids including acne keloidalis nuchae • Hemangiomas (including Buccal, port wine and pyogenic granulomas/granuloma pyogenicum/granuloma telangiectaticum) • Tattoos • Telangiectasia • Removal of small skin tumors, including periungual (Koenen) and subungual fibromas • Superficial pigmented lesions • Adenosebaceous hypertrophy or sebaceous hyperplasia • Rhinophyma reduction […]”

FDA status & indication

Candela CO2RE: FDA ClearedK151655, K181523
Read FDA indication wording
“The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”
Lumenis UltraPulse DUO: FDA ClearedK151331, K203544, K220467
Read FDA indication wording
“The UltraPulse system (UltraPulse and UltraPulse DUO models, members of the modified Lumenis Family of UltraPulse SurgiTouch CO2 Surgical Lasers) is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynecology (including laparoscopy), neurosurgery, orthopedics (soft tissue), arthroscopy (knee), general and thoracic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery. The UltraPulse system (UltraPulse and UltraPulse DUO models, members of the modified Lumenis Family of UltraPulse SurgiTouch CO2 Surgical Lasers) is indicated for use in the performance of specific surgical applications in aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynecology (including laparoscopy), neurosurgery, orthopedics (soft tissue), arthroscopy (knee), general and thoracic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery as follows: Dermatology & Plastic Surgery — The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: • Laser skin resurfacing • Laser derm-abrasion • Laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for treatment of: • Wrinkles, rhytids, and furrows (including fine lines and texture irregularities). Laser skin resurfacing (ablation and/or vaporization) of soft tissue for the reduction, removal, and/or treatment of: • Keratoses, including actinic and seborrheic keratosis, seborrhoecae vulgares, seborrheic wart and verruca seborrheica • Vermillionectomy of the lip • Cutaneous horns • Solar/actinic elastosis • Cheilitis, including actinic cheilitis • Lentigines, including lentigo maligna or Hutchinson's malignant freckle • Uneven pigmentation/dyschromia • Acne scars • Surgical scars • Keloids including acne keloidalis nuchae • Hemangiomas (including Buccal, port wine and pyogenic granulomas/granuloma pyogenicum/granuloma telangiectaticum) • Tattoos • Telangiectasia • Removal of small skin tumors, including periungual (Koenen) and subungual fibromas • Superficial pigmented lesions • Adenosebaceous hypertrophy or sebaceous hyperplasia • Rhinophyma reduction […]”

Which chains run each

Which chains run each: Candela CO2RE vs Lumenis UltraPulse DUO
Attribute	Candela CO2RE	Lumenis UltraPulse DUO
Chain adoption	0 recorded pairings	0 recorded pairings
Chains using it	—	—
Approved reviews	0	0

Chain adoption

Candela CO2RE: 0 recorded pairings
Lumenis UltraPulse DUO: 0 recorded pairings

Chains using it

Candela CO2RE: —
Lumenis UltraPulse DUO: —

Approved reviews

Candela CO2RE: 0
Lumenis UltraPulse DUO: 0

Specs and platform

Specs and platform: Candela CO2RE vs Lumenis UltraPulse DUO
Attribute	Candela CO2RE	Lumenis UltraPulse DUO
Manufacturer	Candela	Lumenis
Built by (OEM)	Syneron Medical Ltd.	Lumenis Be Ltd.
Category	CO2 Fractional/Ablative	CO2 Fractional/Ablative
Technology	Fractional CO2 10600nm dual-ring scanning (CO2 fractional)	CO2 10600nm surgical + aesthetic (CO2 fractional)
Launch year	2011	2015
Status	Current	Discontinued
Manufacturer source record	No linked source on file.	No linked source on file.

Manufacturer

Candela CO2RE: Candela
Lumenis UltraPulse DUO: Lumenis

Built by (OEM)

Candela CO2RE: Syneron Medical Ltd.
Lumenis UltraPulse DUO: Lumenis Be Ltd.

Current alternatives

Current catalog models in related categories. Confirm availability and configuration with the supplier.

Rohrer Aesthetics Phoenix CO2

CO2 Fractional/Ablative

New: $59,995 (Rohrer-advertised price)

Lumenis AcuPulse

CO2 Fractional/Ablative

New: $90k–$130k

DEKA SmartXide Punto

CO2 Fractional/Ablative

New: $60k–$90k

DEKA HELIX

CO2 Fractional/Ablative

New: —

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