Head to head

CO2RE vs SmartSkin+ (2026)

Compare purchase costs, running costs and the evidence behind each device.

Read the comparison overview

Purchase cost: The catalog lists $90k–$120k for CO2RE. No new-price range is on file for SmartSkin+. Check the source notes and request current quotes.
Practice fit: Both are listed under CO2 fractional/ablative. Check each model’s US regulatory status and labeled indications for your intended use.

Device A

CO2 Fractional/Ablative

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Device B

CO2 Fractional/Ablative

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Price comparison

Price comparison: Candela CO2RE vs Cynosure SmartSkin+
Attribute	Candela CO2RE	Cynosure SmartSkin+
New price range	$90k–$120kSource not documented	Not published
Used asking range	$25k–$45kSource not documented	$15k–$30kSource not documented
Payback calculator	View ROI calculator	View ROI calculator
Next step		Explore this model’s specs and owner reviews. For new-equipment inquiries, browse current models. Browse current models

New price range

Candela CO2RE: $90k–$120kSource not documented
Cynosure SmartSkin+: Not published

Used asking range

Candela CO2RE: $25k–$45kSource not documented
Cynosure SmartSkin+: $15k–$30kSource not documented

Payback calculator

Candela CO2RE: View ROI calculator
Cynosure SmartSkin+: View ROI calculator

Next step

Candela CO2RE

Cynosure SmartSkin+

Explore this model’s specs and owner reviews. For new-equipment inquiries, browse current models.

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Consumable economics

Consumable economics: Candela CO2RE vs Cynosure SmartSkin+
Attribute	Candela CO2RE	Cynosure SmartSkin+
Consumable cost / lock-in	Supply pricing is not documented with a dated source yet. Request an itemized supply quote.	—
Service cost	Not published	Not published

Consumable cost / lock-in

Candela CO2RE: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
Cynosure SmartSkin+: —

Service cost

Candela CO2RE: Not published
Cynosure SmartSkin+: Not published

FDA clearance

FDA clearance: Candela CO2RE vs Cynosure SmartSkin+
Attribute	Candela CO2RE	Cynosure SmartSkin+
FDA status & indication	FDA ClearedK151655, K181523 Read FDA indication wording “The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”	FDA ClearedK133895, K081424 Read FDA indication wording “It is indicated for incision, excision, ablation, vaporization and coagulation of body soft tissues in medical specialties including aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynaecology, neurosurgery, orthopaedics, general and thorasic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery. The use with the scanning unit is indicated for ablative skin resurfacing.”

FDA status & indication

Candela CO2RE: FDA ClearedK151655, K181523
Read FDA indication wording
“The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”
Cynosure SmartSkin+: FDA ClearedK133895, K081424
Read FDA indication wording
“It is indicated for incision, excision, ablation, vaporization and coagulation of body soft tissues in medical specialties including aesthetic (dermatology and plastic surgery), podiatry, otolaryngology (ENT), gynaecology, neurosurgery, orthopaedics, general and thorasic surgery (including open and endoscopic), dental and oral surgery and genitourinary surgery. The use with the scanning unit is indicated for ablative skin resurfacing.”

Which chains run each

Which chains run each: Candela CO2RE vs Cynosure SmartSkin+
Attribute	Candela CO2RE	Cynosure SmartSkin+
Chain adoption	0 recorded pairings	0 recorded pairings
Chains using it	—	—
Approved reviews	0	0

Chain adoption

Candela CO2RE: 0 recorded pairings
Cynosure SmartSkin+: 0 recorded pairings

Chains using it

Candela CO2RE: —
Cynosure SmartSkin+: —

Approved reviews

Candela CO2RE: 0
Cynosure SmartSkin+: 0

Specs and platform

Specs and platform: Candela CO2RE vs Cynosure SmartSkin+
Attribute	Candela CO2RE	Cynosure SmartSkin+
Manufacturer	Candela	Cynosure
Built by (OEM)	Syneron Medical Ltd.	Cynosure LLC
Category	CO2 Fractional/Ablative	CO2 Fractional/Ablative
Technology	Fractional CO2 10600nm dual-ring scanning (CO2 fractional)	Fractional CO2 (El.En.-built) (CO2 fractional)
Launch year	2011	2010
Status	Current	Discontinued
Manufacturer source record	No linked source on file.	No linked source on file.

Manufacturer

Candela CO2RE: Candela
Cynosure SmartSkin+: Cynosure

Built by (OEM)

Candela CO2RE: Syneron Medical Ltd.
Cynosure SmartSkin+: Cynosure LLC

Current alternatives

Current catalog models in related categories. Confirm availability and configuration with the supplier.

Rohrer Aesthetics Phoenix CO2

CO2 Fractional/Ablative

New: $59,995 (Rohrer-advertised price)

Lumenis AcuPulse

CO2 Fractional/Ablative

New: $90k–$130k

DEKA SmartXide Punto

CO2 Fractional/Ablative

New: $60k–$90k

DEKA HELIX

CO2 Fractional/Ablative

New: —

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