Head to head

Hybrid vs CO2RE (2026)

Compare purchase costs, running costs and the evidence behind each device.

Read the comparison overview

Purchase cost: Catalog new-price ranges: Hybrid, $120k–$160k; CO2RE, $90k–$120k. Check the source notes and request current quotes.
Practice fit: Both are listed under CO2 fractional/ablative. Check each model’s US regulatory status and labeled indications for your intended use.

Device A

CO2 Fractional/Ablative

View full device profile →

Device B

CO2 Fractional/Ablative

View full device profile →

Price comparison

Price comparison: Alma Hybrid vs Candela CO2RE
Attribute	Alma Hybrid	Candela CO2RE
New price range	$120k–$160kSource not documented	$90k–$120kSource not documented
Used asking range	$70k–$100kSource not documented	$25k–$45kSource not documented
Payback calculator	View ROI calculator	View ROI calculator
Next step

New price range

Alma Hybrid: $120k–$160kSource not documented
Candela CO2RE: $90k–$120kSource not documented

Used asking range

Alma Hybrid: $70k–$100kSource not documented
Candela CO2RE: $25k–$45kSource not documented

Payback calculator

Alma Hybrid: View ROI calculator
Candela CO2RE: View ROI calculator

Next step

Alma Hybrid

Candela CO2RE

Consumable economics

Consumable economics: Alma Hybrid vs Candela CO2RE
Attribute	Alma Hybrid	Candela CO2RE
Consumable cost / lock-in	Supply pricing is not documented with a dated source yet. Request an itemized supply quote.	Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
Service cost	Not published	Not published

Consumable cost / lock-in

Alma Hybrid: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.
Candela CO2RE: Supply pricing is not documented with a dated source yet. Request an itemized supply quote.

Service cost

Alma Hybrid: Not published
Candela CO2RE: Not published

FDA clearance

FDA clearance: Alma Hybrid vs Candela CO2RE
Attribute	Alma Hybrid	Candela CO2RE
FDA status & indication	FDA ClearedK203441, K251230 Read FDA indication wording “The Alma Hybrid Laser System, Delivery Devices, Applicators and Accessories are intended for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery). HyLight-CO2: The Alma Hybrid CO2 non-fractional applicator, with wavelength of 10600 nm is cleared for use for the particular indications as follows: Dermatology & Plastic Surgery — The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: • laser skin resurfacing • laser derm-abrasion • laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) of soft tissue for the reduction, removal, and/or treatment of: warts, acne scars, nevi epidermal, syringoma. Vaporization/coagulation of warts. Pixel: The Alma Hybrid Pixel CO2 fractional applicator, with wavelength of 10600 nm is indicated for: The ablation, vaporization, and coagulation of soft tissue in dermatology and plastic surgery in the performance of skin resurfacing. ProScan: The Alma Hybrid ProScan CO2 fractional applicator, with wavelength of 10600 nm is indicated for: • Laser skin resurfacing (ablation and/or vaporization) of soft tissue. The Alma Hybrid ProScan 1570nm fractional applicator, with wavelength of 1570 nm, is indicated for: • Use in dermatological procedures requiring fractional skin resurfacing and coagulation of soft tissue. The Alma Hybrid ProScan CO2 & 1570nm fractional applicator, with wavelengths of 10600 nm & 1570nm is indicated for laser skin resurfacing (ablation and/or vaporization) of soft tissue.”	FDA ClearedK151655, K181523 Read FDA indication wording “The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”

FDA status & indication

Alma Hybrid: FDA ClearedK203441, K251230
Read FDA indication wording
“The Alma Hybrid Laser System, Delivery Devices, Applicators and Accessories are intended for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery). HyLight-CO2: The Alma Hybrid CO2 non-fractional applicator, with wavelength of 10600 nm is cleared for use for the particular indications as follows: Dermatology & Plastic Surgery — The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: • laser skin resurfacing • laser derm-abrasion • laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) of soft tissue for the reduction, removal, and/or treatment of: warts, acne scars, nevi epidermal, syringoma. Vaporization/coagulation of warts. Pixel: The Alma Hybrid Pixel CO2 fractional applicator, with wavelength of 10600 nm is indicated for: The ablation, vaporization, and coagulation of soft tissue in dermatology and plastic surgery in the performance of skin resurfacing. ProScan: The Alma Hybrid ProScan CO2 fractional applicator, with wavelength of 10600 nm is indicated for: • Laser skin resurfacing (ablation and/or vaporization) of soft tissue. The Alma Hybrid ProScan 1570nm fractional applicator, with wavelength of 1570 nm, is indicated for: • Use in dermatological procedures requiring fractional skin resurfacing and coagulation of soft tissue. The Alma Hybrid ProScan CO2 & 1570nm fractional applicator, with wavelengths of 10600 nm & 1570nm is indicated for laser skin resurfacing (ablation and/or vaporization) of soft tissue.”
Candela CO2RE: FDA ClearedK151655, K181523
Read FDA indication wording
“The CO2RE is indicated for use in surgical applications requiring the ablation, vaporization, excision, incision, and coagulation of soft tissue in medical specialties including: aesthetic surgery (dermatology and plastic surgery), podiatry, gynecology, neurosurgery, orthopedics (soft tissue), arthroscopy (knee). The CO2RE is indicated for dermatological procedures requiring ablation, coagulation and resurfacing of soft tissue, including skin. The Standard Handpiece of the CO2RE System is indicated for the following: Dermatology & Plastic Surgery The ablation, vaporization, excision, incision, and coagulation of soft tissue in dermatology and plastic surgery in the performance of: x laser skin resurfacing x laser dermabrasion x laser burn debridement. Laser skin resurfacing (ablation and/or vaporization) for the treatment of: x wrinkles, rhytids, and furrows (including fines lines and texture irregularities) Clinical literature demonstrates that skin resurfacing of wrinkles, rhytids, and furrows with CO2 laser increases the amount of sub-epidermal collagen.”

Which chains run each

Which chains run each: Alma Hybrid vs Candela CO2RE
Attribute	Alma Hybrid	Candela CO2RE
Chain adoption	0 recorded pairings	0 recorded pairings
Chains using it	—	—
Approved reviews	0	0

Chain adoption

Alma Hybrid: 0 recorded pairings
Candela CO2RE: 0 recorded pairings

Chains using it

Alma Hybrid: —
Candela CO2RE: —

Approved reviews

Alma Hybrid: 0
Candela CO2RE: 0

Specs and platform

Specs and platform: Alma Hybrid vs Candela CO2RE
Attribute	Alma Hybrid	Candela CO2RE
Manufacturer	Alma	Candela
Built by (OEM)	Alma Lasers Ltd.	Syneron Medical Ltd.
Category	CO2 Fractional/Ablative	CO2 Fractional/Ablative
Technology	CO2 10600nm + 1570nm fiber hybrid (CO2 fractional)	Fractional CO2 10600nm dual-ring scanning (CO2 fractional)
Launch year	2021	2011
Status	Current	Current
Manufacturer source record	No linked source on file.	No linked source on file.

Manufacturer

Alma Hybrid: Alma
Candela CO2RE: Candela

Built by (OEM)

Alma Hybrid: Alma Lasers Ltd.
Candela CO2RE: Syneron Medical Ltd.

Current alternatives

Current catalog models in related categories. Confirm availability and configuration with the supplier.

Rohrer Aesthetics Phoenix CO2

CO2 Fractional/Ablative

New: $59,995 (Rohrer-advertised price)

Lumenis AcuPulse

CO2 Fractional/Ablative

New: $90k–$130k

DEKA SmartXide Punto

CO2 Fractional/Ablative

New: $60k–$90k

DEKA HELIX

CO2 Fractional/Ablative

New: —

Get a free recommendation Browse by goal

Device and company names are trademarks of their respective owners. The Aesthetic Index is not affiliated with or endorsed by any manufacturer, distributor or lender named here, except as disclosed. Price figures are references, not current offers. Check each device’s source notes. Not medical, legal or regulatory advice.